Influence of metallothionein-1 localization on its function

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Influence of metallothionein-1 localization on its function.

Metallothioneins (MTs) have a major role to play in metal metabolism, and may also protect DNA against oxidative damage. MT protein has been found localized in the nucleus during S-phase. The mRNA encoding the MT-1 isoform has a perinuclear localization, and is associated with the cytoskeleton; this targeting, due to signals within the 3'-untranslated region (3'-UTR), facilitates nuclear locali...

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ژورنال

عنوان ژورنال: Biochemical Journal

سال: 2001

ISSN: 0264-6021

DOI: 10.1042/0264-6021:3550473